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When the microvilli come in contact with amino acids, long and short chain fatty acids, glucose and other stimuli, such as bile acids, acetylcholine, or signals created when the intestine stretches, they release GLP-1, along with other hormones, into the bloodstream[2]

GLP-1 receptor agonists are medications that mimic the effects of GLP-1 by binding to and activating the GLP-1 receptors