Potential signs and symptoms include: Skin Raised, reddish patches covered with thick, silvery-white, shiny scales, which may be itchy Pinpoint bleeding spots appear when scales are scraped off (Auspitz sign) Systemic Fever, dehydration, and elevated white blood cell count may occur in severe cases Other Joint stiffness or pain, including inflammation or damage in psoriatic arthritis Diagnosis The diagnosis of psoriasis is based on a physical examination of the skin, scalp, and nails
However, this may reflect no more than its relative potency as a prostaglandin inhibitor: common therapeutic doses of 12gm/day reduce prostaglandin formation by ~50% in comparison to the more complete suppression by other tNSAIDs like ibuprofen [82]
doi: 10.1159/000506129
Conversely, low-dose GLP-1 therapy is not appropriate for patients without established indications, particularly those seeking anti-inflammatory effects alone without diabetes or obesity
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