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Chronic treatment with anti-bipolar drugs causes intracellular alkalinization in astrocytes, altering their functions

Acetyl-L-carnitine dose-dependently increased rCMRglc in the prefrontal, cingulate, and somatosensory cortices, in the cortical amygdala and in the accumbens, diagonal band, dorsal raphe, and locus coeruleus nuclei (ANOVA and unpaired t -test, P 60 years) undergoing cardiac and non-cardiac surgery, pre-incisional KET (0.5 or 1 mg/kg) did not decrease post-operative pain, delirium, or depressed mood ( Most negative studies focused on post-operative pain