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Transmission electron microscopy of Raji cells Untreated Raji cells, Raji cells treated with TPA for 24 h, Raji cells treated with TPA and 200 ng/ml TNF-, cells treated with 10 M erastin and 10 M Fer-1 sh-NC and sh-GPX4 cells were collected and fixed by the addition of electron microscope fixative (G1102 Servicebio) for 2 h at 4 C

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This work was partly supported by the Tohoku Medical Megabank Project from MEXT, Japan Agency for Medical Research and Development (AMED

Nonclinical programs should include organ-system panels, cardiovascular telemetry where appropriate, and full pathology review to characterize off-target consequences of chronic ERR activation