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Type 2 Diabetes and Weight Loss Therapies: The Hype, Hope, and Your Heart GLP-1 drugs were once met with skepticism, but now their proven health benefits have brought them unprecedented levels of hype

Here we defined a signature of 59 genes and two metabolites (GSH and NADP) that is robustly associated with NRF2 dependency across an extensive panel of cancer cell lines

doi: 10.1111/and.v51.10 102 MajzoubAAgarwalA

Concerning research gaps and opportunities, Rinaman pointed to whether perinatal development of the GLP-1/GLP-1R system may help explain individual differences in responsiveness to GLP-1R agonists, why there are sex differences in the endogenous GLP-1/GLP-1R system and why GLP-1R agonists are more effective for weight loss in women than in men, and whether chronic exposure to GLP-1R agonists affects central GLP-1 receptors

As a harm reduction specialist, I feel it is key to discuss the risks posed by the use of these products. Primary risks relate to routes of consumption the majority of these products in New Zealand require injection