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If you notice heightened nausea after even small amounts of alcohol, this is your body signaling reduced tolerance

doi:10.1016/S0040-4039(03)00028-5 Sher N, Siddiqui FA, Fatima N et al (2015) New method development for hydroxyzine determination: application in stability studies, pharmaceutical formulations, and humane serum

This arm of the mechanism is also believed to drive PCSK9 degradation, which appears to lower LDL cholesterol in clinical readouts