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Abbreviations ABC1: More advantaged social grades (includes managerial, professional, and upper supervisory occupations) AUDIT-C: Alcohol Use Disorders Identification Testconsumption BMI: Body mass index C2DE: Less advantaged social grades (includes manual routine, semi-routine, lower supervisory, state pension, and long-term unemployed) GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 GP: General practitioner K6: Kessler Psychological Distress Scale NHS: National Health Service NICE: National Institute for Health and Care Excellence References NHS Digital

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Dulaglutide, liraglutide, and exenatide caused less diarrhea than tirzepatide and semaglutide