is the price of tirzepatide going down Zepbound cut: Eli Lilly lowers cost weight loss drug How Much Does Zepbound (Tirzepatide)

Another potential benefit is that by taking a GLP-1, you might be able to counter the weight-gain-inducing effects of other medications you take for mental health

10.1002/jbmr.2564 Summary Keywords glucagonlike peptide1 receptor agonist, randomized controlled trial, older adults, bone mineral density, bone turnover Citation Dinkla L, Beavers KM, Robbins R, Akpalu D, Wherry SJ, Miller G, Beavers DP, Espinoza S, Trejo J, Stepanenko A and Cortes TM (2025) Bone mineral density and turnover response to GLP-1 receptor agonists in older adults with overweight/obesity and prediabetes/type 2 diabetes: a 20-week pilot trial post hoc analysis

The trial evidence is strongest for concentrations in the 0.1% to 1% range

Staying hydrated and eating smaller, protein-rich meals helps manage these effects

Most people running it describe the effect as "things just working a bit better" particularly for visceral fat reduction that plateaued on GLP-1 therapy alone