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Taken together, these results demonstrate that hepatic GSH depletion induces a functional adaption in the transcriptional program, leading to decreased lipid accumulation and fibrosis in liver, and these effects are predominantly intrinsic to hepatocytes

doi: 10.3389/fphar.2024.1337282 Received 12 November 2023 Accepted 18 March 2024 Published 02 April 2024 Volume 15 - 2024 Edited by Jia-You Fang, Chang Gung University, Taiwan Reviewed by Sergio Alberto Bernal Chvez, Universidad de las Amricas Puebla, Mexico Zhixing Wu, University of Florida, United States Andr Rolim Baby, University of So Paulo, Brazil Updates Copyright 2024 Ghasemiyeh, Fazlinejad, Kiafar, Rasekh, Mokhtarzadegan and Mohammadi-Samani

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Grass-dominated pastures pose more of a risk for deficiency

A series of mutants impaired in other genes putatively involved in glutathione homeostasis were however not more susceptible than WT