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The gradual escalation serves two purposes: it allows the body to adapt to GLP-1 receptor activation (reducing nausea), and it permits glucagon receptor effects to build progressively without overwhelming metabolic pathways

2.3 Mechanisms linking gut microbiota dysbiosis to hypothyroidism development Gut microbiota dysbiosis exerts significant impacts on multiple physiological systems, directly and indirectly exacerbating the pathogenesis of hypothyroidism through several interconnected mechanisms

[DOI] [PMC free article] [PubMed] [Google Scholar] 66.Mastrandrea L.D., Witten L., Carlsson Petri K.C., Hale P.M., Hedman H.K., Riesenberg R.A