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Efficacy of sublingual and oral vitamin B12 versus intramuscular injection

Lancet 386 (9991), 376387

Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications

Maintenance: 300500 mcg 23 times/week TB + daily BPC

Additionally, all experimental procedures involving animals were performed in accordance with the institutional guidelines and regulations for the care and use of experimental animals and complied with the relevant national ethical standards