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This pattern suggests continuous daily Dihexa administration beyond 4-6 weeks without rest periods would likely trigger protective receptor downregulation, reducing compound effectiveness over time

Furthermore, in mice subjected to CLP, the expression of active heparanase increases within the first 4 h of AKI, most markedly in the glomerulus and small periglomerular arteries (96)

A nearly 25% average weight reduction in less than a year is unprecedented in the published literature

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