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This article reports the landmark trial comparing the effects of semaglutide and tirzepatide at their maximum tolerated doses in adults with obesity, or with overweight and at least one prespecified comorbidity

Unger et al., 2016), but also with aging in humans in general (Duncan and Flint, 2013) and with an Alzheimer-like condition in mice (Zhang et al., 2017)

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Information about four weeks on semaglutide with no weight loss , for example, is most actionable when accompanied by data showing whether caloric intake was adequate, whether protein targets were met, and whether injection adherence was complete during that period