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Sci Rep 6:117

However, despite the progress in the development of GLP-1 analogues, the overall efficacy of GLP-1 analogues for weight loss is still limited by gastrointestinal side effects, in particular nausea at higher doses (45)

Foods with high polyphenols include spinach, green tea, apples, celery, asparagus, coffee and berries

Therefore, Tac full blood concentration in patients with anemia or hypalbuminemia may be underestimated, which may result in higher toxicity after increasing the Tac dose to maintain target trough levels ( For its therapeutic effect, Tac binds to and forms a complex with FKBP12 in lymphocytes and inhibits the activity of calcineurin ( Tacrolimus is extensively distributed in the whole body but its distribution in solid organ tissue behaves similarly to lymphocytes and is dependent on P-gp expression and intracellular metabolism