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doi:10.1016/j.endmts.2025.100228

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Tirzepatide works on both GLP-1 and GIP receptors, which may provide additional metabolic benefits and stronger appetite regulation for some individuals

To sum up, once-weekly semaglutide offers markedly greater weight loss and better treatment persistence than once-daily liraglutide when both are used alongside lifestyle counseling in adults with overweight or obesity without diabetes