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There is also an increased risk of pancreatitis with GLP-1s

Here, the C-peptide slowly cleaves away under the action of peptidase enzymes, allowing proinsulin to metamorphose into insulin and C-peptide molecules

A general cut-off of the eGFR of less than 30 mL/min/1.73 m 2 can also be used as a guide for referral, but ideally, the severity of albuminuria should also be taken into account, which may warrant the involvement of a nephrologist before arriving at this eGFR cut-off

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Un metaanlisis72, que incluy 25 estudios clnicos aleatorizados para evaluar la presencia de eventos adversos serios como pancreatitis aguda y cncer con el uso de la liraglutida y el exenatide, document no asociacin de estos frmacos con dichos eventos, y se concluy que no hay evidencia suficiente para considerar que estos eventos sean desencadenados por las incretinas