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But the nearly 50% risk of retained solid food in patients who underwent upper endoscopy without a clear liquid diet the day beforehand were far higher than we anticipated. On the other hand, we found that no patients undergoing concurrent endoscopy with colonoscopy who consumed a clear liquid diet the day prior to the procedure had retained solid food

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Furthermore, the endogenous peptide Agouti-related peptide (AgRP), which is an inverse agonist on MC4R and a competitive antagonist or ERK-biased agonist on MC3R, is known to increase food intake and body weight (30, 31)