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4.1 Prognostic nutritional index (PNI) The PNI is one of the earliest and most widely used nutritional-immune assessment tools, first proposed by the Japanese scholar Onodera in 1984 for gastrointestinal surgery patients

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Finally, a four-year, multicenter, clinical trial in 421 diabetic patients with distal symmetric sensorimotor polyneuropathy found no difference between oral administration of 600 mg/day of lipoic and placebo on the primary endpoint, a composite score that assessed neuropathic impairment of the lower limbs and nerve conduction (78)