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That triple mechanism produced the most dramatic weight reduction data in modern clinical trials, with participants losing up to 24.2% of their body weight over 48 weeks

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Chambers RC, Leoni P, Kaminski N, Laurent GJ, Heller RA: Global expression profiling of fibroblast responses to transforming growth factor-beta1 reveals the induction of inhibitor of differentiation-1 and provides evidence of smooth muscle cell phenotypic switching

Of note, excessive IFN- production occurring in more than half of all SLE patients stimulates the release of interferongenic DNA (including mtDNA) from neutrophils, forming an autoantigen/antibody immune complex (71)