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Hyperglycemic memory of innate immune cells promotes in vitro proinflammatory responses of human monocytes and murine macrophages

Stability in all three age groups was lower at the compositional level than at the functional level (Figure 7E)

The physiological significance of these changes remains to be determined

By interrupting a key proteinprotein interaction that allows senescent cells to persist, FOXO4-DRI offers the potential to selectively eliminate those cells and thus improve tissue function, reduce inflammation, and restore aspects of youthful physiology

No claims are made regarding medical, therapeutic, cosmetic, or clinical outcomes.