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Most gastrointestinal side effects of tirzepatide, including nausea and diarrhea, are most severe during the first few weeks of treatment or after dose increases and typically diminish within several days to weeks as the body adapts to the medication

Patients with documented B12 sensitivity or MTHFR methylation variants should ask their provider about the Tirzepatide/Glycine variant instead

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Chavda VP et al

The study in the New England Journal of Medicine also found that taking the drug can lead to a smaller waistline and lower blood pressure