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GLP-1

Most people reach effective plateau by week 48-60, with minimal additional loss even with continued treatment

Patients continuing treatment beyond six months often see sustained or additional weight loss into month 912, depending on adherence and dose optimization

Practical tip A combination of SGLT2i and GLP-1RA might theoretically improve cardiorenal benefits in patients with T2D and either ASCVD or multiple risk factors for ASCVD whose A1c remains suboptimal despite initial treatment with only one of these agents or if clinical status changes (e.g., new onset HF or CKD

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