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This tripeptide is composed of three amino acids: glutamate, cysteine, and glycine

Both medications commonly cause nausea, vomiting, and diarrhea during dose escalation, though tirzepatide's GIP pathway may increase gastrointestinal effects in some patients

In November, Pfizer won its bidding war against Novo Nordisk to acquire the metabolic startup Metsera for $10 billion. With multiple agents demonstrating 15% to 20% reductions in baseline body weight, weight loss alone is now a prerequisite

It is an execution challenge

In the trial of 1,961 adults without TD2M, who had either a body mass index (BMI) of 30 or more, or a BMI of 2729 and at least one comorbidity, those taking semaglutide achieved an average of 14.9% body weight loss at 68 weeks, compared with 2.4% in those who received placebo