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Sci Transl Med (2014) 6(223):223ra23

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Phase III RECONNECT Trials FDA Approval Dataset The Phase III RECONNECT trials (RECONNECT-1 and RECONNECT-2) a pair of randomised, double-blind, placebo-controlled, multicentre studies enrolled approximately 1,247 premenopausal women with HSDD across North America and confirmed statistically significant improvements in the number of satisfying sexual events and reduction in distress from low sexual desire with bremelanotide 1.75 mg subcutaneous vs placebo

The acquired resistance is driven to some extent by intra-tumor heterogeneity, mainly directed by cancer stem cells (CSCs)