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Moreover, SFN is considered to possess negligible toxic effects and effectively traverses the bloodbrain barrier in mice after intraperitoneal administration, potentially increasing brain-derived neurotrophic factor (BDNF) levels and enhancing dendritic spine density due to its direct impact on neurons, while also providing protection against oxidative stress via the Keap1-Nrf2 pathway (102)

Prim Care Companion CNS Disord 2025;27(4):25cr03931 Submitted: January 31, 2025