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As the essential eNOS cofactor tetrahydrobiopterin (BH 4 ) is susceptible for oxidation, a landmark study by David Harrison's group 62 was able to proof the concept that superoxide produced by the Nox may indeed trigger eNOS uncoupling in the experimental animal model of DOCA-salt hypertension

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Measurement of Homocysteine written by Dr Gillian Hart BSc (Hons), PhD, Cert Mgmt (Open), MIBMS The importance of homocysteine as a risk factor is becoming much more familiar as evidence grows