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The designed ASOs mask the dysfunctional exon in the pre-mRNA, resulting in the exon being spliced out of the final mRNA transcriptthus restoring the reading frame and producing a partially functioning copy of the dystrophin protein [92, 97] (Fig

Recovery time is moderate, with swelling and bruising sometimes lingering for up to a week

The analysis of genotoxicity showed that the hyperthyroid rat models heart and lungs had a higher percentage of DNA fragmentation than those of the euthyroid animals

Vemulapalli R, Kurosawa M, Killinger J, et al