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The secondary efficacy endpoint was the proportion of subjects achieving complete (melasma score 0) or near-complete (melasma score 1) clearing by Week 8

The overuse and misuse of antibiotics further speed up the phenomenon as the bacteria can evade the effects of these drugs by applying selection pressure on them and allowing resistance genes to spread and enhance the resistance of the microbial communities in Fig

Raven Press, New York, 1992

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One example is protein A (ligand), which can be utilized to purify immunoglobulin G antibodies (target protein)