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If endometriotic lesions rely on aberrant metabolism for survival, medications that correct metabolic dysfunction could theoretically undermine the metabolic support those lesions depend on

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Subsequently, the local membrane is destabilized due to the change in curvature stress and internal osmotic pressure

A recent phase 2 trial investigated the triple biased GLP-1/GIP/GCC receptors agonist retatrutide (LY3437943) in 338 patients with a mean age of 48 years and BMI of 37.3 kg/m 2 without diabetes (prediabetes in 36% participants) showing BW and WC reduction ranging from 8.7% to 24.2% and 6.5 cm to 19.6 cm in the 1 mg and 12 mg dose groups, respectively, at 48 weeks 41

The cost comparison makes it starker