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In vivo experiments, icariin reduced ferroptosis alleviated atherosclerotic lesions, and increased TFEB nucleation rate
In hepatocellular carcinoma (HCC) cells, post-translational activation of cystathionine -synthase (CBS) under TNF-induced oxidative stress increases TSS activity through a proteolytically cleaved and highly active form of CBS, increasing cystathionine and GSH production (102), which in turn promotes tumor progression and inhibits ferroptosis
10.1186/s40168-020-00955-1 Microbiome 81 JarretA.JacksonR.DuizerC.HealyM
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