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Ozempic has a boxed warning for thyroid cancer and MEN-2 syndrome, as mentioned in the FDAs label

V., Caldeira, C

The mutation of GLP-1 Phe 28 to Ala causes it to lose nearly all of its affinity (IC 50 : 0.27 nM357 nM), and Ile 29 mutation decreases the affinity notably (IC 50 : 0.27 nM25 nM), while Trp 31 , Leu 32 , and Val 33 mutations have little influence, showing that they may be merely subsidiary

Curcumin increases ADAMTS18 gene expression and restores ccRCC sensitivity to sunitinib, and this regulation can be reversed by ferroptosis inhibitors, indicating that curcumin mediates ferroptosis in ccRCC through ADAMTS18 (178)