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It means that our understanding of it must expand to include the bidirectional communication between gut, brain, immune system, and behavior

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[DOI] [PMC free article] [PubMed] [Google Scholar] 28.Zeng N., Cutts E.J., Lopez C.B., Kaur S., Duran M., Virkus S.A., Hardaway J.A

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Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006