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Knockouts of the ThDP transporter SLC44A4 in mice display an upregulation of genes associated with colonic inflammation, and increased susceptibility to dextran sodium sulfate-induced colitis, accompanied by significant weight loss and shortening of the colon (204)

doi: 10.1002/ptr.1085

One study has shown that one year after stopping weekly doses of semaglutide, of participants regained the lost weight and saw a similar rebound of cardiometabolic variables

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No, you should rotate injection sites each week to prevent tissue damage, lipohypertrophy, and increased injection-site reactions