Constant injection in the same exact spot can lead to skin irritation or the development of small lumps called lipohypertrophy, which can interfere with how the medication is absorbed
In my years of clinical practice, Ive identified five distinct types of obesityeach with different underlying causes: Caloric Obesity : Simply consuming more calories than your body burns Inflammatory Obesity : Where chronic inflammation triggers fat storage and prevents fat-burning Metabolic Obesity : Involving insulin resistance, hormonal imbalances, and a damaged metabolism Microbiome Obesity : When gut bacteria imbalances hijack your appetite and metabolism Chemical Obesity : Exposure to obesogensenvironmental chemicals that disrupt your bodys weight regulation Theres also a crucial neurological factor: When your nervous system stays in fight-or-flight mode, your body doesnt feel safe enough to release weight
For context, as of July 31, 2025, the FDA recorded 605 reports of adverse events tied to compounded semaglutide and 545 reports linked to compounded tirzepatide
And, fortunately, many of the things that help you manage or lose weight are the very same things that can help alleviate symptoms of depression
[3] This is most common when you first start taking GLP-1s or when you increase your dosage
