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Nutrients, 10 (2)

Long-term substance abuse often reduces the brains ability to produce feel-good chemicals like dopamine, making recovery challenging

This means the FDA does not review these drugs to evaluate their safety, effectiveness, or quality before they are marketed." (Source: FDA "Compounding and the FDA: Questions and Answers".) Clinical efficacy data such as the 14.9% mean weight loss from the STEP 1 trial or the 22.5% from SURMOUNT-1 comes from studies of the FDA-approved formulations, not from compounded versions

Florez JC (2017) The pharmacogenetics of metformin

From there, a licensed provider determines whether compounded options, or any GLP-1 format, are right for your situation