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The Food and Drug Administration said, For healthy adults, the FDA has cited 400 milligrams a day thats about four or five cups of coffee as an amount not generally associated with dangerous, negative effects. Drinking over 400 mg of caffeine could potentially lead to serious conditions like heart and kidney problems, anxiety, paranoia and more

(1996) Pharmacokinetics of orally and intravenously administered riboflavin in healthy humans