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This macrophage reprogramming is associated with SFN-mediated inhibition of the transcription factor c-Myc, which normally drives M2 polarization, and concurrent activation of the Nrf2 pathway that favors M1-associated gene expression profiles (78)

Therefore it has the ability to antagonize all the peripherally mediated side effects of narcotics (mostly constipation) without reducing the analgesic effects (which are mediated within the CNS)

Journal of the International Society of Sports Nutrition, 15 (26)