Melatonin restored the expression of genes involved in glycolysis (HK2, ENO1, PKM1, LDHA) and the TCA cycle (CS, IDH1, SUCLA2, FH, MDH1), reversed HO-induced metabolic disorders, increased the activity of mitochondrial oxidative phosphorylation complexes (II, III, and V), and increased the efficiency of ATP generation to safeguard the energy requirements of oocytes
However, there is currently no available data assessing the efficacy of these medications specifically for the treatment of BED
It may improve skin elasticity and subjects muscle mass, which eventually contributes to a fresh appearance
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GDP: Guanosine diphosphate