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Patients with higher baseline HbA1c values tend to experience greater absolute reductions, and response should be reassessed around three months after starting treatment in line with NICE NG28

Similarly, injecting into the same spot repeatedly creates scar tissue and lipohypertrophy, both of which impair medication uptake and may require dose adjustments to maintain efficacy

Cardiovascular outcomes (e.g., SELECT and SOUL trials), 2

Resistance mechanisms towards CD38-Directed antibody therapy in multiple myeloma

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