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We simulated the effect of joint CLP257 and L838,417 administrations under the assumption each drugs works on a distinct effector namely KCC2 activity for CLP257 and g inh for L838,417

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4 This is the same vagal circuit that Samsoms pramlintide study implicated: the gastric-emptying delay is a brain-to-stomach command relayed down the vagus, not a peptide throttling the pylorus directly

PMID: 9 Mannochio-RussoHCharron-LamoureuxVvan FaassenMLamichhaneSNunesWDGDelerayVet al