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In Japanese patients with hyperuricemia who were studied in detail, heritable ABCG2 dysfunction was observed in up to half of the study population investigated, and its population-attributable contribution to hyperuricemia was as high as 30%, much higher than the contribution of non-genetic factors such as overweight/obesity, heavy alcohol consumption and aging

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Strikingly, reduced production of IL-21 by CD4 + T cells, and decreased frequency of IFN--expressing CD4 + T cells and CD8 + T cells were observed in the presence of L-Cn ( Figures 3C, D )