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Within seconds of the sensing of increased reactive oxygen species (ROS), several enzymes of glycolysis (particularly glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase) are inhibiting allowing for the diversion of glucose carbons into the PPP

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Figueroa-Romero C, Hur J, Bender DE, Delaney CE, Cataldo MD, Smith AL et al (2012) Identification of epigenetically altered genes in sporadic amyotrophic lateral sclerosis