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This combination is designed around nightly use consistency matters more than almost anything else here

One side effect that some patients report is a fast heart rate, also known as tachycardia

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Diabet Med 26:268278 Nauck M, Frid A, Hermansen K et al (2009) Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study