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Also consider the time aspect taking a pill at home is free and fast, whereas an IV session requires an appointment

In summary, the kinetic data for the E170X mutants support a glutaredoxin-catalysed formation of GSSEtOH as well as an exclusive interaction between Glu170 and the glutathione moiety of GSSR in accordance with the glutathione-scaffold model

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The loading doses are generally smaller, fractionated injections designed to steadily increase receptor exposure without overwhelming the system in a single large bolus

Skorjanec et al., 2009