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In the DXA subgroup (n = 252), the data showed that 67% of the weight reduction originated from fat mass and 33% from lean soft tissue

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Carbonyl cyanide m-chlorophenyl hydrazine renders the inner mitochondrial membrane permeable to H+, leading to membrane potential destabilisation on both sides of the inner mitochondrial membrane, and then, via the Pink1-Parkin pathway, which is specific for membrane potential destabilisation, the mitochondria undergo further membrane potential (MMP) hyperpolarisation, which generates ROS