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While etiologic subtypes are frequently used to neatly organize CHE for the purpose of diagnostic and therapeutic guidelines, they frequently coexist and evolve over time, which can make strict clinical classification challenging from patient-to-patient [3, 4, 5, 23]

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NADPH dependence of inhibition TGR was incubated at room temperature with inhibitor in the presence or absence of 100 M NADPH for 15 min