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Woo et al, 1997)

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Several studies have implied that FXR activation relieves intestinal inflammatory state in IBD patients, as well as that colonic inflammation in patients with CD and in rodent models of colitis is linked to diminished expression of FXR mRNA (Vavassori et al., 2009)

For instance, it has been shown that after an experimental psychologic stress, the evoked cortisol response in fatigued breast cancer survivors is much smaller than that in nonfatigued ones, pointing to the involvement of the HPA axis in cancer-related fatigue (286)