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Am J Clin Nutr 89: 71-76.

The hepatocarcinogenicity of peroxisome proliferators in rodents involves several members of this heterogeneous group of agents (Evans and Lake 1998)

Oxidative damage has been linked to high levels of eryptosis through an increase in the intracellular free Ca 2+ concentration, as evidenced by in vitro studies [24, 134, 300, 301] in patients intoxicated with lead [302], and in diabetic patients with chronic renal damage [303]

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This microvascular rarefaction is likely a key contributor to the reduced muscle endurance observed in IGF- 1R KD mice, as capillary networks are critical for sustaining aerobic metabolism and preventing muscle fatigue [58, 62, 63]