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311 The crystal structure of PbrR suggests that the Pb II -selectivity of this switch may be traced to the coordination geometry itself, where fourth coordination position is occupied by the stereochemically active lone pair of electrons on the Pb II ion

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Researchers at Monash University in Australia first isolated the fragment in the late 1990s, hypothesizing it could reproduce the lipolytic (fat-burning) effects of growth hormone without triggering the diabetogenic and growth-promoting side effects [1]

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