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Cooperation between paediatric and adult hepatologists will be essential in the next years

Because of this origin, it is studied as a potential communicator between mitochondria and the rest of the cell, a role researchers refer to as retrograde mitochondrial signaling

Triggers of elevated ceramide levels comprise hyperosmotic shock [122], secreted sphingomyelinases (SMases) during inflammation [125], sepsis [126] or severe coronavirus disease 2019 (COVID-19) [127], Clostridium perfringens epsilon toxin [128], and platelet-activating factor [129]

They slow gastric emptying, increase insulin release, and suppress appetite at the brain level

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